abstract：OBJECTIVES:The purpose of this study was to evaluate the efficacy and safety of different doses of anthracyclines combined with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for induction in newly diagnosed acute promyelocytic leukemia (APL). METHODS:One hundred and forty patients were included between Jan...

authors： Wu Y,Ke P,Zhou H,Wu D,Chen S,Qiu H,Han Y,Li C,Ma X,Sun A,Tang X,Hu X

更新日期：2021-12-01 00:00:00

abstract：:Older adults (50 years and over) are still sexually active and therefore vulnerable to unplanned pregnancy, infection of STIs and HIV, yet there are no programmes in place to cater for their family planning needs. The objective of the study is to show how some socio-economic characteristics of older adults influence t...

authors： Ama NO,Olaomi JO

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Allium cepa L. (Liliaceae), known as onion, is consumed throughout the world. Onion and its derivatives including saponins, aglycones, quercetin, cepaenes, flavonoids, organosulfurs, and phenolic compounds, showed various pharmacological properties and therapeutic effects. OBJECTIVE:Anti-inflammatory, antioxid...

authors： Marefati N,Ghorani V,Shakeri F,Boskabady M,Kianian F,Rezaee R,Boskabady MH

更新日期：2021-12-01 00:00:00

abstract：:This paper explores how Burundian adolescents in the Nakivale refugee settlement, Uganda, experience umwidegemvyo, loosely translated as "freedom", with regard to their sexuality. We draw on ethnographic research conducted between August and November 2017 with adolescents aged 13-19 years. Our research included in-dep...

authors： Ruzibiza Y,Berckmoes L,Neema S,Reis R

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Poria coco F.A.Wolf (Polyporaceae) dispels dampness and promotes diuresis implying hypouricaemic action. OBJECTIVE:To examine hypouricaemic action of Poria coco. MATERIALS AND METHODS:Ethanol extract (PCE) was prepared by extracting the sclerotium of P. cocos with ethanol, and the water extract (PCW) was prod...

authors： Liang D,Yong T,Diao X,Chen S,Chen D,Xiao C,Zuo D,Xie Y,Zhou X,Hu H

更新日期：2021-12-01 00:00:00

abstract：:Cryptococcal meningitis is a fungal infectious disease with a poor prognosis and high mortality. Amphotericin B (AMB) is the first choice for the treatment of cryptococcal meninges. The blood-brain barrier (BBB) is the major barrier for the effective delivery of drugs to the brain. In this study, AMB was incorporated ...

authors： Lin W,Xu T,Wang Z,Chen J

更新日期：2021-12-01 00:00:00

abstract：:Liquid-liquid phase separation (LLPS) mediated formation of membraneless organelles has been proposed to coordinate biological processes in space and time. Previously, the formation of phase-separated droplets was described as a unique property of HP1α. Here, we demonstrate that the positive net charge of the intrinsi...

authors： Qin W,Stengl A,Ugur E,Leidescher S,Ryan J,Cardoso MC,Leonhardt H

更新日期：2021-12-01 00:00:00

abstract：OBJECTS:This study aimed to analyze the clinicopathological features of acute kidney disease (AKD) with renal oxalosis. METHODS:Data for biopsy-proven AKD with oxalosis diagnosed from Jan 2011 to Oct 2018 was collected. The underlying diseases, dietary habits, clinical and pathological characteristics of newly emergin...

authors： Zhou J,Yu X,Su T,Wang S,Yang L

更新日期：2021-12-01 00:00:00

abstract：:Mimics account for almost half of hospital admissions for suspected stroke. Stroke mimics may present as a functional (conversion) disorder or may be part of the symptomatology of a neurological or medical disorder. While many underlying conditions can be recognized rapidly by careful assessment, a significant proport...

authors： H Buck B,Akhtar N,Alrohimi A,Khan K,Shuaib A

更新日期：2021-12-01 00:00:00

abstract：:Purpose: The scarcity of resources, especially in Lesotho rural schools, obstruct the holistic well-being of learners with visual impairments (LVIs). Moreover, the voices of LVIs are often missing about the use of resources to improve their well-being. The study explored an asset-based approach for the improvement of ...

authors： Ramatea MA,Khanare FP

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Patients with chronic kidney disease (CKD) often have structural abnormalities of the heart due to pressure and volume overload. The aim of this study was to evaluate associations between echocardiographic parameters and renal outcomes (estimated glomerular filtration rate [eGFR] slope and progression to dia...

authors： Huang TH,Chiu H,Wu PY,Huang JC,Lin MY,Chen SC,Chang JM

更新日期：2021-12-01 00:00:00

abstract：:As a high-risk factor of perinatal HBV transmission, the potential role of maternal hepatitis B e antigen (HBeAg) to guide antiviral prophylaxis has not yet been fully reported. This large prospective cohort study enrolled 1177 hepatitis B surface antigen (HBsAg)-positive pregnant women without antiviral treatment and...

authors： Lu Y,Song Y,Zhai X,Zhu F,Liu J,Chang Z,Li Y,Xiao Y,Li L,Liu M,Liu J,Duan Z,Zou H,Zhuang H,Wang J,Li J

更新日期：2021-12-01 00:00:00

abstract：:To date, there is no final FDA-approved treatment for COVID-19. There are thousands of studies published on the available treatments for COVID-19 virus in the past year. Therefore, it is crucial to synthesize and summarize the evidence from published studies on the safety and efficacy of experimental treatments of COV...

authors： Wadaa-Allah A,Emhamed MS,Sadeq MA,Ben Hadj Dahman N,Ullah I,Farrag NS,Negida A

更新日期：2021-12-01 00:00:00

abstract：:Background: The Faroese people constitute a geographically isolated population, and research on cancer in this population is sparse. Thus, this study aimed to calculate the age-standardised incidence rate (ASIR) and 5-year survival rates in head and neck cancers (HNC) in the Faroese population from 1985 to 2017.Materi...

authors： Olsen SH,Friborg J,Ellefsen B,Jakobsen KK,Aanæs K

更新日期：2021-12-01 00:00:00

abstract：:Catalase is one of the most abundant enzymes on Earth. It decomposes hydrogen peroxide, thus protecting cells from dangerous reactive oxygen species. The catalase-encoding gene is conspicuously absent from the genome of most representatives of the family Trypanosomatidae. Here, we expressed this protein from the Leish...

authors： Sádlová J,Podešvová L,Bečvář T,Bianchi C,Gerasimov ES,Saura A,Glanzová K,Leštinová T,Matveeva NS,Chmelová Ľ,Mlacovská D,Spitzová T,Vojtková B,Volf P,Yurchenko V,Kraeva N

更新日期：2021-12-01 00:00:00

abstract：:Acute Coronary Syndromes (ACS) with plaque erosion display dysregulated hyaluronan metabolism, with increased hyaluronidase-2 (HYAL2) expression. However, the expression and the role of this enzyme on platelets has never been explored. We evaluated the platelet's HYAL2 (pltHYAL2) levels on I) stable angina (SA) and II...

authors： Vinci R,Pedicino D,D'Aiello A,Ciampi P,Ponzo M,Bonanni A,Russo G,Montone RA,Massetti M,Crea F,Liuzzo G

更新日期：2021-12-01 00:00:00

abstract：:Countless studies have demonstrated that Circular RNAs (circRNAs) exert vital effects in regulating tumorigenesis of various cancers. CircRNA ZNF609 (circ-ZNF609) has been reported as an oncogene in various human cancers. Nevertheless, its regulating effect in cervical cancer (CC) remains to be further explored. RT-qP...

authors： Gu Q,Hou W,Shi L,Liu H,Zhu Z,Ye W

更新日期：2021-12-01 00:00:00

abstract：:Bloodstream infections (BSIs) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) are potentially life-threatening and an urgent threat to public health. The present study aims to clarify the characteristics of carbapenemase-encoding and virulent plasmids, and their interactions with the host bacterium. A tota...

authors： Yang Y,Yang Y,Chen G,Lin M,Chen Y,He R,Galvão KN,El-Gawad El-Sayed Ahmed MA,Roberts AP,Wu Y,Zhong LL,Liang X,Qin M,Ding X,Deng W,Huang S,Li HY,Dai M,Chen DQ,Zhang L,Liao K,Xia Y,Tian GB

更新日期：2021-12-01 00:00:00

abstract：:Coxsackievirus A6 (CV-A6) has been emerging as a major pathogen of hand, foot and mouth disease (HFMD). Study on the pathogenesis of CV-A6 infection and development of vaccines is hindered by a lack of appropriate animal models. Here, we report an actively immunized-challenged mouse model to evaluate the efficacy of a...

authors： Qian SS,Wei ZN,Jin WP,Wu J,Zhou YP,Meng SL,Guo J,Wang ZJ,Shen S

更新日期：2021-12-01 00:00:00

abstract：:An 8-year-old neutered male Yorkshire Terrier dog presented with head pressing, vestibular ataxia, neck tenderness, and no oculocephalic reflex. A demarcated lesion in the pons was identified on MRI. The patient was tentatively diagnosed with a glioma and was treated with hydroxyurea plus imatinib and prednisolone. Af...

authors： Yun T,Koo Y,Kim S,Lee W,Kim H,Chang D,Kim S,Yang MP,Kang BT

更新日期：2021-12-01 00:00:00

abstract：:Small molecule modulators of mitochondrial function have been attracted much attention in recent years due to their potential therapeutic applications for neurodegenerative diseases. The mitochondrial translocator protein (TSPO) is a promising target for such compounds, given its involvement in the formation of the mi...

authors： Kim T,Morshed MN,Londhe AM,Lim JW,Lee HE,Cho S,Cho SJ,Hwang H,Lim SM,Lee JY,Lee J,Pae AN

更新日期：2021-12-01 00:00:00

abstract：:Sub-Saharan Africa was historically considered an animal influenza cold spot, with only sporadic highly pathogenic H5 outbreaks detected over the last 20 years. However, in 2017, low pathogenic avian influenza A(H9N2) viruses were detected in poultry in Sub-Saharan Africa. Molecular, phylogenetic, and antigenic charac...

authors： Fusade-Boyer M,Djegui F,Batawui K,Byuragaba DK,Jones JC,Wabwire-Mangeni F,Erima B,Atim G,Ukuli QA,Tugume T,Dogno K,Adjabli K,Nzuzi M,Adjin R,Jeevan T,Rubrum A,Go-Maro W,Kayali G,McKenzie P,Webby RJ,Ducatez MF

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Uremic encephalopathy is defined as cerebral dysfunction due to toxin accumulation in patients with chronic kidney disease (CKD). This condition is characterized by subtle to florid symptoms, and its clinical course is always progressive when untreated but partially reversible with renal replacement therapy....

authors： Sanchez-Meza F,Torre A,Castillo-Martinez L,Sanchez-Roman S,Morales-Buenrostro LE

更新日期：2021-12-01 00:00:00

abstract：:PE_PGRS proteins of Mycobacterium tuberculosis (Mtb) constitute a large family of complex modular proteins whose role is still unclear. Among those, we have previously shown, using the heterologous expression in Mycobacterium smegmatis, that PE_PGRS3 containing a unique arginine-rich C-terminal domain, promotes adhesi...

authors： De Maio F,Salustri A,Battah B,Palucci I,Marchionni F,Bellesi S,Palmieri V,Papi M,Kramarska E,Sanguinetti M,Sali M,Berisio R,Delogu G

更新日期：2021-12-01 00:00:00

abstract：:The present study describes evaluation of epigenetic regulation by a small molecule as the therapeutic potential for treatment of Huntington's disease (HD). We identified 5-allyloxy-2-(pyrrolidin-1-yl)quinoline (APQ) as a novel SETDB1/ESET inhibitor using a combined in silico and in vitro cell based screening system. ...

authors： Hwang YJ,Hyeon SJ,Kim Y,Lim S,Lee MY,Kim J,Londhe AM,Gotina L,Kim Y,Pae AN,Cho YS,Seong J,Seo H,Kim YK,Choo H,Ryu H,Min SJ

更新日期：2021-12-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is an emerging zoonotic pathogen of canine origin that causes an array of fatal diseases, including bacteremia and endocarditis. Despite large-scale genome sequencing projects have gained substantial insights into the genomic landscape of MRSP, current knowl...

authors： Bünsow D,Tantawy E,Ostermeier T,Bähre H,Garbe A,Larsen J,Winstel V

更新日期：2021-12-01 00:00:00

abstract：:The correlation between oral bacteria and dental implants failure has been reported. However, the effect and mechanism of bacteria during dental implants is unclear. In this study, we explored key genes and candidate gene clusters in human gingival fibroblasts (HGF) cells in response to Streptococcus oralis biofilm th...

authors： Chen X,Ma J

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Current medicine for Alzheimer's disease (AD) cannot effectively reverse or block nerve injury. Traditional Chinese Medicine practice and research imply Aconiti lateralis Radix Praeparata (Fuzi) may meet this goal. OBJECTIVE:Analysing the anti-AD effect of Fuzi and its potential molecular mechanism. MATERIALS...

authors： Wang Y,Zhang H,Wang J,Yu M,Zhang Q,Yan S,You D,Shi L,Zhang L,Wang L,Wu H,Cao X

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:Ginger (Zingiber officinale Roscoe) is considered to be one of the most commonly consumed dietary condiments of the world. The present study was designed to explicate the protective role of zingerone; an active ingredient of ginger in complete Freund's adjuvant (FCA)-immunized arthritic rats. METHODS:24 Wist...

authors： Bashir N,Ahmad SB,Rehman MU,Muzamil S,Bhat RR,Mir MUR,Shazly GA,Ibrahim MA,Elossaily GM,Sherif AY,Kazi M

更新日期：2021-12-01 00:00:00

abstract：:Data on genome organization and output over time, or the 4D Nucleome (4DN), require synthesis for meaningful interpretation. Development of tools for the efficient integration of these data is needed, especially for the time dimension. We present the '4DNvestigator', a user-friendly network-based toolbox for the analy...

authors： Lindsly S,Chen C,Liu S,Ronquist S,Dilworth S,Perlman M,Rajapakse I

更新日期：2021-12-01 00:00:00

abstract：:Coronavirus Disease (COVID-19) has caused global mental health impacts, and healthcare workers (HCWs) face an increased risk of exposure to the disease when compared to the general population. This study aimed to assess factors associated with mental health among Lebanese HCWs six months after the start of the COVID-1...

authors： Msheik El Khoury F,Talih F,Khatib MFE,Abi Younes N,Siddik M,Siddik-Sayyid S

更新日期：2021-12-01 00:00:00

abstract：:Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question of immunity generated by a single infection is sufficient to provide sterilizing/protective immunity to a subsequent...

authors： Brustolin M,Rodon J,Rodríguez de la Concepción ML,Ávila-Nieto C,Cantero G,Pérez M,Te N,Noguera-Julián M,Guallar V,Valencia A,Roca N,Izquierdo-Useros N,Blanco J,Clotet B,Bensaid A,Carrillo J,Vergara-Alert J,Segalés J

更新日期：2021-12-01 00:00:00

abstract：:As the most common histologic subtype of renal cancer, clear cell renal cell carcinoma (ccRCC) poses a serious threat to public health. However, there are no specific molecular-targeted drugs for ccRCC at present. Human ATP-binding cassette (ABC) transporter family plays an important role in homeostasis maintenance. T...

authors： Meng F,Xiao Y,Xie L,Liu Q,Qian K

更新日期：2021-12-01 00:00:00

abstract：:Incidence vs. Cumulative Cases (ICC) curves are introduced and shown to provide a simple framework for parameter identification in the case of the most elementary epidemiological model, consisting of susceptible, infected, and removed compartments. This novel methodology is used to estimate the basic reproduction rati...

authors： Lega J

更新日期：2021-12-01 00:00:00

abstract：:International electives are recognized as a high-impact practice in clinical education. However, medical students' actual learning experiences during electives have not been explored fully. Specifically, drawing on language management theory, this exploratory case study investigates students' perceived learning outcom...

authors： Imafuku R,Saiki T,Hayakawa K,Sakashita K,Suzuki Y

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:This study aims to identify potential prognostic biomarkers of bladder cancer (BCa) based on large-scale multi-omics data and investigate the role of SRC in improving predictive outcomes for BCa patients and those receiving immune checkpoint therapies (ICTs). METHODS:Large-scale multi-comic data were enrolled ...

authors： Xu W,Anwaier A,Ma C,Liu W,Tian X,Palihati M,Hu X,Qu Y,Zhang H,Ye D

更新日期：2021-12-01 00:00:00

abstract：:Axis deer (Axis axis) occur both in captivity and free-ranging populations in portions of North America, but to-date, no data exist pertaining to the species' susceptibility to CWD. We sequenced the prion protein gene (PRNP) from axis deer. We then compared axis deer PrPC sequences and amino acid polymorphisms to thos...

authors： Buchholz MJ,Wright EA,Grisham BA,Bradley RD,Arsuffi TL,Conway WC

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Resveratrol has shown anti-stress and anti-depressant-like abilities involved in inhibiting phosphodiesterase-4 (PDE4) enzyme. However, its application is limited due to its low efficacy, bioavailability and selectivity. OBJECTIVE:This study synthesized a new resveratrol derivative RES003 and evaluated its PDE...

authors： Yu Y,Wang J,Huang X

更新日期：2021-12-01 00:00:00

abstract：:We evaluated the survival of a subarctic population and the significance of traditional risk factors for mortality, causes of death and their seasonal variation from the period of 1984-2014. By the end of 2014 (follow-up), 644 (34.4% from 1,869) participants had died (42.1% of cardiovascular causes, 22.4% of neoplasti...

authors： Perkkiö Y,Auvinen J,Timonen M,Jokelainen J,Valkeapää N,Koiranen M,Saltevo J,Keinänen-Kiukaanniemi S

更新日期：2021-12-01 00:00:00

abstract：:Macrophages are a major component of the immunoresponse. Diversity and plasticity are two of the hallmarks of macrophages, which allow them to act as proinflammatory, anti-inflammatory, and homeostatic agents. Research has found that cancer and many inflammatory or autoimmune disorders are correlated with activation a...

authors： Song S,Xia H,Guo M,Wang S,Zhang S,Ma P,Jin Y

更新日期：2021-12-01 00:00:00